Interaction of Cholera Toxin with Three Life-cycle Stages of Schistosoma mansoni: Adult Worm, Egg and Cercaria
نویسندگان
چکیده
منابع مشابه
Serological Screening of the Schistosoma mansoni Adult Worm Proteome
BACKGROUND New interventions tools are a priority for schistosomiasis control and elimination, as the disease is still highly prevalent. The identification of proteins associated with active infection and protective immune response may constitute the basis for the development of a successful vaccine and could also indicate new diagnostic candidates. In this context, post-genomic technologies ha...
متن کاملSm14 gene expression in different stages of the Schistosoma mansoni life cycle and immunolocalization of the Sm14 protein within the adult worm.
Sm14 is a 14-kDa vaccine candidate antigen from Schistosoma mansoni that seems to be involved in cytoplasmic trafficking of fatty acids. Although schistosomes have a high requirement for lipids, they are not able to synthesize fatty acids and sterols de novo. Thus, they must acquire host lipids. In order to determine whether Sm14 is present in different stages of the life cycle of the parasite,...
متن کاملSchistosoma mansoni cercaria and schistosomulum antigens in serodiagnosis of schistosomiasis.
Schistosoma mansoni cercaria and schistosomulum obtained in vitro were used in immunofluorescence (IF) tests and indirect hemagglutination (IHA) tests of 137 study sera, 44 from subjects infected with S. mansoni and 93 from healthy subjects residing outside areas endemic for the disease. The results of these tests were compared with those obtained by testing the same sera using conventional adu...
متن کاملViability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM)
Infection with helminth parasites causes morbidity and mortality in billions of people and livestock worldwide. Where anthelmintic drugs are available, drug resistance is a major problem in livestock parasites, and a looming threat to public health. Monitoring the efficacy of these medicines and screening for new drugs has been hindered by the lack of objective, high-throughput approaches. Seve...
متن کاملStructural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae.
Immune responses induced by glycans upon infection with Schistosoma mansoni may be mediated by either schistosomal glycoproteins or glycosphingolipids. In this study, we have elucidated the structural features of both carbohydrate moieties and respective ceramide units of complex glycosphingolipids from adult S. mansoni. Obtained data revealed a vast structural heterogeneity due to manifold com...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2007
ISSN: 0300-9475,1365-3083
DOI: 10.1111/j.1365-3083.2006.01868.x